Description Microbiome data analysis tools will be implemented in a web platform called Enthera, which, because it is entirely cloud-based, needs no information technology infrastructure or software installation at the user end. This means that microbiome analysis will be possible in several contexts, including clinical, research and commercial settings. In addition, the streamlined seamless design of Enthera means that it is not only scalable, modular and easy to use, but also facilitates microbiome raw data processing and interpretation without the need for any training in bioinformatics. Interpretation modules will eventually be added to Enthera that will translate analysed data into potential clinical applications. Objectives The ultimate goal is to translate the clinical knowledge obtained from all other MISTRAL WPs into the Enthera diagnostic tool and so enable streamlined raw sequence analysis by users who may not have bioinformatic skills. Enthera will provide a research user interface for standard state-of-the-art data analysis and, most importantly, will offer application-focused interpretation layers based on correlates and diagnostic/prognostic markers obtained as outcomes of MISTRAL projects. Overall objectives are as follows:

1. To implement high-throughput sequence analysis in a computational cloud infrastructure
2. To offer a web-based data exploration software engine
3. To translate clinical knowledge into clinical application-centred report layers.