Workpackages The tasks of the project are organized in work packages, units of work with different objectives. WP1 Microbiome correlates of HIV-1 protection and control WP2 Modulation of HIV-1 immunotherapy (HTI vaccine) WP3 HTI vaccine randomized clinical trial WP4 Gut microbiome correlates of serious AIDS/non-AIDS events WP5 Impact of antiretroviral therapy in the gut bacterial resistome WP6 Randomized clinical trials of interventions to modulate the gut microbiome in HIV-1 infected adults WP7 Data integration and systems biology WP8 Microbiome-based patient stratification software WP9 Regulatory aspects WP10 Management, exploitation and communication activities WP11 Ethical requirements